Applications of Drug Metabolites in Medicine

Drug metabolites are compounds produced by the chemical transformation of drugs in the body. They are related to the safety and effectiveness of the drug. Over the past two decades, there has an increasing focus on the importance of pharmacokinetic data in the drug discovery process. The metabolism of a new drug by the host system is one of the most important determinants of its pharmacokinetic disposition[1]. In some instances, metabolic transformation of drugs can also produce reactive or toxic intermediates or metabolites, which have potential toxicological implications[2]. Hence, there is a need to insight into the metabolic process of a new drug early in the drug discovery process, which relies on the study of drug metabolites. Alfa Chemistry is an expert of drug metabolites, we have the ability to provide professional advice on your drug research.

Applications of Drug Metabolites in Medicine

Applications of drug metabolites include, but are not limited to the following.

  • Drug metabolites can be used to determine the use or abuse of illicit drugs. For example, urinalysis, often looks for the presence of drug metabolites, rather than the actual drug.
  • Drug metabolites play a significant role in new drug discovery and research. Safety testing of drug metabolites has the potential to provide data support for the clinical use of drugs.
  • Drug metabolites can help determine pharmacokinetic data by testing their concentration, which is useful for analyzing the degree of drug absorption.
  • Drug metabolites offer possibilities for the development and application of other new drugs. This is because drug metabolites may produce special activity after being processed in the body.

  • References

    1. Stachulski, A.V.; et al. The generation, detection, and effects of reactive drug metabolites. Medicinal Research Reviews. 2013, 5(33): 985-1080.
    2. Kumar, G.N.; Surapaneni, S. Role of drug metabolism in drug discovery and development. Medicinal Research Reviews. 2001, 5(21): 397-411.

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