Alfa Chemistry Blog

The compounds conjugated with PEG (functional PEGs) have many advantages. Ever since its discovery, PEGylation is of increasing interest in biological and medical studies owing to their solubility in water, excellent biocompatibility and non-immunogenicity. The US-based chemical supplier Alfa Chemistry announces in a recent statement that it starts to provide functional PEGs for scientific research. Polyethylene glycol (PEG) is a versatile polyether compound being utilized in various areas ranging from industrial manufacturing to medicine. In the process of PEGylation, PEG is bonded to another molecule to accomplish certain goal. Now PEGylation has become an attractive and promising therapeutic method. “The importance of PEG in drug delivery lies in its ability to hinder the protein adsorption and thus minimize the protein corona formation,” says the Marketing Chief of Alfa Chemistry. “In general, PEG can be conjugated to many chemicals such as peptide, low molecular weight drugs,...

Due to its biological inertness and good biocompatibility, polyethylene glycol (PEG) has a wide range of applications in the pharmaceutical industry, biological materials, cosmetics, and analytical science. A number of compounds, such as proteins, peptides, oligonucleotides, drugs and liposomes, after being modified by PEG covalent bonding, can effectively extend the circulation time in the body, increase stability, optimize pharmacokinetics and reduce side effects. Functional PEG has huge potentials in different scenarios. According to MarketsandMarkets, the global PEG-modified drug market in 2017 was 10.388 billion U.S. dollars, and is expected to reach 17.813 billion U.S. dollars by 2025, with a significant growth rate. As of the end of 2019, 26 PEGylated drugs have been approved by the FDA or the European Union. Except for 2 small molecule drugs and 1 liposome drug, the remaining 23 are all PEGylated protein/peptide drugs. On the whole, PEGylation can be used for PEGylated pro...