Alfa Chemistry Blog

  Introduction Fluorouracil is a white to nearly white crystalline powder that is sparingly soluble in water and alcohol. The chemical name of it is 5-fluoro-2,4(1H,3H)-pyrimidinedione. Fluorouracil is a cytotoxic chemoradiotherapy medication used to treat rectal cancer, head and neck cancer, esophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer by intravenous injection. The structure is shown in fig. 1. Fig. 1 Structure of fluorouracil Application in the treatment of cancer Fluorouracil can be used in the treatment of multiple cancers. Several examples are described below [1] . Rectal cancer Fluorouracil has effectively employed in chemoradiotherapy for rectal cancer, significantly improving survival in palliative treatment. Recently, preoperative chemoradiotherapy with fluorouracil infusion has demonstrated superiority compared with surgery or external beam radiation alone in nonrandomized studies. Sixteen recent studies involving more than 100...

Introduction Sulfamethoxazole  is a crystal or white powder with the chemical name N-(5-methyl-3-isoxazolyl)-4-aminobenzenesulfonamide. It is a sulfonamide bacteriostatic antibiotic that is effective against gram negative and positive bacteria such as  Listeria monocytogenes  and  E.coli . It is mainly used in the treatment of bacterial infections such as urinary tract infections, bronchitis, and prostatitis. The structure is shown in fig. 1. Fig. 1 Structure of sulfamethoxazole Application in the treatment of bacterial infections Sulfamethoxazole was introduced to the United States in 1961. It is now mostly used in combination with trimethoprim. The combination has been included on the WHO Model List of Essential Medicines as a first-choice to treat urinary tract infections. Introduction of bacterial infections Bacterial infections are any illness or condition caused by bacterial growth or toxicity. They may affect your skin, lungs, brain, blood and other parts of y...

As one of the leading chemical manufacturers and suppliers globally, Alfa Chemistry is well-prepared to provide a number of active pharmaceutical ingredients (APIs) ,  such as donepezil and dexmedetomidine hydrochloride ,  for customers worldwide ranging from lab to commercial scale . Earlier this month, the company  announced that three other APIs ha d  been introduced for its global customers as well, namely, lenalidomide, parecoxib sodium, and rivaroxaban. “ With highly skilled Ph.D. and M.S. synthetic chemists as well as advanced technological facilities , we are able to meet the highest manufacturing standards  to synthesize innovative small molecul ar  APIs for pharmaceutical companies across the world, ”  said t he Marketing Chief of Alfa Chemistry . “ Throughout the manufacturing process, we focus extensively  on the safety of API production on the one hand and pay attention to ensure all quality standards and cGMP requirements   are ...

  Having established close cooperative relations with many pharmaceutical companies, universities, and research institutions, Alfa Chemistry decided to enlarge its active pharmaceutical ingredient (API) supply continuously in the hope of providing a more diversified product portfolio for customers. Fairly recently, the company announced the launch of   dexmedetomidine hydrochloride , another API demanded in large quantities for both pharmaceutical preparation and scientific research. Dexmedetomidine hydrochloride is the salt form of dexmedetomidine, an imidazole derivative and active d-isomer of medetomidine consisting of analgesic, anxiolytic, and sedative activities. In order to make surgeries safer, more comfortable, and painless for patients, many hospitals are willing to introduce dexmedetomidine hydrochloride to improve the sufficiency of anaesthesia. Overall, dexmedetomidine hydrochloride can be used for general anaesthesia, local anaesthesia, spinal anaesthesia, and ne...