Alfa Chemistry Blog

  What Is PROTAC Technology? Proteolytic targeting chimera (PROTAC) is a new type of drug design technology that works by inducing the degradation of target proteins. Unlike conventional small molecules that typically inhibit protein function, PROTACs facilitate the ubiquitination and subsequent degradation of specific proteins. This bifunctional molecule consists of two distinct elements: a ligand that engages a target protein of interest and a second ligand that recruits the E3 ubiquitin ligase, a component of the ubiquitin-proteasome system responsible for protein tagging for degradation. By linking these two components, PROTACs create a bridge that brings the target protein into proximity with the E3 ligase, leading to its ubiquitination and degradation. Currently, there are more than 160 PROTAC projects under development worldwide, of which nearly 20 projects are in clinical development. These projects involve a variety of disease targets, including cancer, inflammation, and n...

In cosmetics, the application of plant extracts has been particularly popular because of their various advantages and natural nature. Plant Extracts for Moisturizing Skincare relies upon moisturization, and plant extracts are the stepping stones to that. Plant extracts also have hydroxyl groups in the polysaccharides and glycosides that keep water inside them with hydrogen bonds. The majority of plant polysaccharides are hygroscopic like aloe polysaccharides which are the active constituents of aloe extracts and are used in cosmetics as moisturizing raw materials. Moreover, the majority of water-soluble plant polysaccharides like cactus polysaccharides, astragalus polysaccharides, schizonepeta polysaccharides and dendrobium officinale polysaccharides absorb water well. Plant Extracts for Barrier Repairing Barrier repair agents help in building the skin barrier function and skin health during the skin care. Phytoelements such as licorice root, green tea, chamomile etc help to repair and...

  A Quantum Dot Kit is a comprehensive set of materials and tools designed for the synthesis and handling of quantum dots. Quantum dots are tiny semiconductor particles, typically ranging from 2 to 10 nanometers in size. They possess unique optical and electronic properties due to their quantum confinement effects, making them highly attractive for a wide range of applications. What are the Applications of Quantum Dot Kit? The application of Quantum Dot Kit in various industries and fields showcases its immense potential and advantages. Quantum Dot Kit has shown great promise in the field of medicine and bioimaging. The unique optical properties of quantum dots, such as their strong fluorescence and size-tunable emissions, enable their usage in various biomedical applications. They can be utilized as effective contrast agents for in vivo imaging, facilitating better visualization of tissues and organs. Quantum dots can also be functionalized with biomolecules for targeted drug...